The island, though small, contains a large number of secrets and interconnected pathways.
Principally, two interconnected pathways regulate this adaptive response.
It should be born in mind that differentiation and cell cycling are interconnected pathways, and thus it is expected that p53, shown to be involved in both, is a key factor in coordinating these pathways.
Rather than being separate processes, light signalling pathways and circadian control are interconnected pathways, with photoreceptors being involved in timing of the clock, while the clock regulates expression of photoreceptor genes (for review see [30]).
Translation, folding and secretion are interconnected pathways that draw on the same cellular resources.
Therefore, p73 and p53 regulation of self-renewal and differentiation should imply independent, yet interconnected pathways.
These advantages of DERA are particularly useful to identify subnetworks across interconnected pathways.
Our results also show that the induced genes unique to susceptible BMdMs fall into different interconnected pathways.
Taken together, these results indicate that lung necrosis and neutrophil influx are common pathways that are likely to reflect multiple different mechanisms or interconnected pathways.
For instance, it has been described that Rho GTPases and Wnt signaling are highly interconnected pathways that can influence hepatocarcinogenesis (Lechel and Rudolph, 2008).
According to current concepts, apoptosis can be induced via at least two distinct, but interconnected pathways that activate different initiator caspases, that is, caspase-8 and -9, which converge at the level of executioner caspase-3, -6, and -7.
