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The regulation of sphingolipid metabolism is complex, incompletely understood, and involves a network of multiple interconnected mechanisms [6, 61].
Disease pathogenesis in amyotrophic lateral sclerosis (ALS) involves a number of interconnected mechanisms all resulting in the rapid deterioration of motor neurons.
The existence of two separate, although interconnected, mechanisms underlying the what- and why- of understanding was confirmed by a behavioral study in humans.
Delineating the relative contribution of these interconnected mechanisms to disease onset is a major challenge.
In mammals, the genome-wide DNA demethylation occurs through several interconnected mechanisms, both passive and active.
Aging influences the arterial wall through two basic interconnected mechanisms: structural and dynamic.
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Post-translational modification of histones, ATP-dependent chromatin remodeling, and DNA methylation are interconnected nuclear mechanisms that ultimately lead to the changes in chromatin structure necessary to carry out epigenetic gene expression control.
81 In view of the complex etiology and multiple interconnecting mechanisms involved in hepatic insulin resistance and nonalcoholic fatty liver disease, 82, 83 many therapeutic approaches can be envisaged, the main ones being summarized here.
The most straightforward methodology for designing a multi-core architecture is to replicate an off-the-shelf core design multiple times, and then connect the cores together using an interconnect mechanism.
While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of their co-regulation are still largely unknown.
Although it is straightforward to understand how a single feedback loop shapes molecular noise, it is far more difficult to understand composite behavior of multiple mechanisms interconnected in complex architecture of gene networks [ 1, 8, 9].
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