The most straightforward methodology for designing a multi-core architecture is to replicate an off-the-shelf core design multiple times, and then connect the cores together using an interconnect mechanism.
Post-translational modification of histones, ATP-dependent chromatin remodeling, and DNA methylation are interconnected nuclear mechanisms that ultimately lead to the changes in chromatin structure necessary to carry out epigenetic gene expression control.
81 In view of the complex etiology and multiple interconnecting mechanisms involved in hepatic insulin resistance and nonalcoholic fatty liver disease, 82, 83 many therapeutic approaches can be envisaged, the main ones being summarized here.
While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of their co-regulation are still largely unknown.
Although it is straightforward to understand how a single feedback loop shapes molecular noise, it is far more difficult to understand composite behavior of multiple mechanisms interconnected in complex architecture of gene networks [ 1, 8, 9].
Although both mechanisms are interconnected, in this review we will mainly discuss the second mechanism and focus on mammalian cells, although current knowledge in yeast will also be described.
Sensing and adhesion mechanisms are interconnected since biofilm formation is regulated by a chemosensory system [ 20].
Taken together, these results indicate that lung necrosis and neutrophil influx are common pathways that are likely to reflect multiple different mechanisms or interconnected pathways.
The changes reported here affecting epigenetic marks and cell wall polymers are associated with the accumulation of auxin in early embryo cells, this data could reflect different processes that are interconnected in complex regulatory mechanisms that control cell reprogramming and embryogenesis initiation.
Interestingly, epigenetic mechanisms are closely interconnected, and specific miRNAs can modulate epigenetic signatures through different mechanisms, including targeting of methyltransferases [ 45].
