A biochip dynamic flow system on which resides one or more separate, but microfluidically interconnected, compartments has been developed to contain cultures of living cells drawn from and/or representing different organs or tissues of a living animal (Chao et al., 2009; Novik et al., 2010; Maguire et al., 2009).
Three types of MBONs and one type of DAN interconnect multiple compartments.
We identified three MBONs and one DAN type that appear to interconnect different compartments of the MB lobes.
Microfluidic channels interconnecting the compartments permit compounds contained in "blood surrogate" culture medium, to re-circulate through and past the respective cell chambers, emulating the circulatory system of a living animal.
In addition, the functional meaning and the localization of all the molecules involved in capacitation were studied and the nodes that interconnect the intracellular compartments were identified.
The model, presented as a set of ordinary differential equations (ODEs), consists of functional compartments interconnected by mass flow.
Rapid fission and fusion of membranes can make compartments functionally interconnected, like the Golgi body's many cisternae, but our "snapshots" of flash-frozen cells suggest that some ER compartments are physically isolated at least part of the time.
Note that the transport of APP among these compartments indirectly interconnects these three compartments to one another.
These compartments are interconnected inside the lobes and the MBONs send converging outputs (color-coded arrows) to small subregions within five neuropils: the lateral horn (LH), CRE, SMP, SIP, and SLP.
First, in contrast to the dendrites of MSN, recurrent axon collaterals of these neurons may cross subregional (shell-core) or compartmental (patch-matrix) boundaries in the ventral striatum and in this way interconnect these functionally different subregions or compartments.
