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However, unlike small-molecule drugs, a biopharmaceutical that is repeatedly interchanged with a similar biological agent may exhibit immunogenicity that could compromise the efficacy and safety of both medications.
Fig. 7 shows that every one of the 27 trajectories involves periods of both speeding up (coloured green) and slowing down (coloured red), frequently interchanging between the two modes repeatedly.
Interchanging mutation.
Interchange: Jake Friend, Shannon Boyd, Trent Merrin, Michael Morgan, Valentine Holmes.
In one interchange, Christine C. Quinn, the City Council speaker, interrupted Mr. Longhi repeatedly when it became clear he would not say what caused the blast.
Mr. Rubenstein said he had repeatedly and unsuccessfully lobbied Fandango's executives to enter into a so-called interchange agreement, in which the sites would essentially share listings.
Interchange: Michael Morgan, Sam Thaiday, Josh Papalii, Josh McGuire.
We interchange.
Biotic interchange.
Interchange Kaye, James, Bryan, Bolger.
Interchange Sargent, Jones, Higgins, Thompson.
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CEO of Professional Science Editing for Scientists @ prosciediting.com