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The presence of significant amounts of protease aminopeptidase Y and the intercellular location of the G. graminis LOX suggest the LOX is not secreted but is effectively intracellular degraded.
Tolerance of normal ocular flora is achieved by the presence of a minimal number of professional antigen presenting cells, immunosuppressive substances in tears, and the strategic intra- and intercellular location of the Toll-like receptors.
This indicates AS can modulate protein functions of Aux/IAAs through regulating their intercellular location.
Previous studies suggested that the intercellular location of ESE-1 is determined by nuclear localization and nuclear export signals [ 21, 22].
However, the intercellular location of proteins that results from VLPs delivery requires evaluation of the efficiency of cytosolic access, and the immunogenicity and safety of viral proteins in VLPs needs to be further determined by in vivo studies.
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Immunofluorescence microscopy of polarized T84 monolayers infected for 24 h with C. jejuni revealed a redistribution of the TJ transmembrane protein occludin from an intercellular to an intracellular location associated with a change in phosphorylation [ 41].
Thus, it is believed that the membranous expression of ALCAM reflects the maintenance of intercellular stability and that the cytoplasmic location, resulting from rearrangement of the intercellular junctions, characterizes tumor cells with high potential for invasion and metastasis [ 23].
The full-length protein sequences of all the PRs we identified here possess an amino-terminus signal peptide, indicating that their location in plants is the intercellular space.
Overexpression of Pbx neither significantly alters En2 location nor interferes with its intercellular transfer (secretion and internalisation) properties (supplementary material Fig. S3), although internalisation was occasionally slightly reduced.
34, 35 Sufficiently slow cell rolling permits firm cell adhesion events mediated by endothelial intercellular adhesion molecule-1 (ICAM-1) at locations of transendothelial migration.
These data combined with the location of E-cadherin in the intercellular space suggested that the paracellular translocation pathway was the likely route for toxin complex entry (Lee et al., 2014).
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