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KLK5-staining revealed intercellular expression pattern at the same area.
In the future either experiments involving a combination of intercellular expression of certain proteins with extracellular treatment of others, or attempting to infect cultured MSCs with live HIV virus (possibly using methodologies similar to that used by Wang et al. [ 32]), are likely areas of future study as we attempt to extend this hypothesis.
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These results showed the direct evidence of intercellular miRNA expression heterogeneity, which differed substantially for individual miRNAs.
Overall levels of intercellular gene expression heterogeneity are comparable across the three conditions.
To further investigate the mechanism of decreased leukocyte-endothelial adhesion by nicotine exposure, the effect of nicotine on endothelial cell intercellular adhesion molecule expression and neutrophil integrin expression of CD62L, CD11a, and CD11b were examined.
Studies of genetically homogenous cell lines with similar intercellular heterogeneous GAGE expression showed that GAGE expression was not associated with a specific genotype, but defined a phenotypically distinct population of cells.
CONCLUSION: Nicotine exerts inhibitory effects on both endothelial cell surface intercellular adhesion molecule expression and neutrophil integrin expressions of CD62L, CD11a, and CD11b in vitro.
At concentrations between 0.10 and 10 μmol/L, nicotine inhibited intercellular adhesion molecule expression in a dose-dependent manner.
RESULTS: Nicotine at a lower concentration of 0.01 μmol/L had no effect on endothelial cell surface intercellular adhesion molecule expression compared with controls (P =.614).
The purpose of this study was to determine syncytiotrophoblast intercellular adhesion molecule 1 expression in villitis and in normal chorionic villi from term 37-422 weeks of gestation) placentas with or without villitis.
This brief review will focus on emerging human platelet miRNA studies to emphasize their potential role relevant to transfusion medicine field in terms of regulating platelet signaling pathways, markers of platelet associated disorders, and remote impactors of gene expression (intercellular biomodulators) as well as potential platelet quality markers of storage and pathogen reduction treatments.
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