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Ember, S. W. et al. Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors.
So far, it is known that ergotamine interacts with diverse receptors (including α1/2-adrenoceptors, 5-HT1, 5-HT2 and D2-like receptors) and that produces increases in mean blood pressure which are significantly blocked by yohimbine, a classical α2-adrenoceptor antagonist with a moderate affinity for α1-adrenoceptors.
These results suggested that FbpABp interacts with diverse ferric siderophores to mediate iron transport to the cytosol.
One major family, the netrins, interacts with diverse single pass cell surface receptors to mediate cell repulsion, attraction or adhesion in tissues, which include the nervous system, vasculature, lung, pancreas, mammary gland and muscle (Lai Wing Sun et al, 2011).
RAGE (receptor for advanced glycation end products), a member of the immunoglobulin superfamily of cell surface molecules, interacts with diverse ligands, including not only advanced glycation end products (AGEs) and β-sheet fibrils, but also several members of the S100 protein family (S100B, S100P, S100A4, S100A6, S100A8/9, S100A11 13), high mobility group box-1 (HMGB1), and prions [ 9, 10].
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It is speculated that for a particular protein, the more it is unstructured, the more is its possibility to interact with diverse partners, and hence the interaction network of the protein becomes large and complex [28].
Thus, mutant p53 may interact with diverse gene promoters in addition to its known interactions with different proteins.
We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein ligand interactions.
With these domains, they interact with diverse regulatory factors.
Besides DNA, Alba proteins also interact with diverse RNA species and associate with ribonucleo-protein complexes.
In addition to plant conservation, Cornell Botanic Gardens offers a beautiful place for people to interact with diverse plant life.
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