This confirms that genes interacting with two or more other genes prefer closed triplet motifs to linear or branched configurations, consistent with other reports showing that physical and genetic interactions tend to cluster together and to interact reciprocally within modules [ 29- 31].
We describe here what we call cooperative invasion, during which heterogeneous melanoma cell subpopulations interact reciprocally and mobilize collectively.
According to the outcomes of previous studies, it is true that psychosocial, physical, and environmental factors interact reciprocally with healthy aging [ 65, 69, 70].
Importantly, because the HPA axis, sympathetic system, and immune system interact reciprocally as part of a larger stress-regulation system, downregulation of one system will have a correlative impact on the functioning of the other systems.
Furthermore, these three pathways interact reciprocally within the mechanism of the mouse segmentation clock (Dequeant and Pourquie, 2008; Gibb et al., 2010; Maroto et al., 2012; Niwa et al., 2007).
Therefore, the onset of dysregulated Notch pathway, that is, as a consequence of mutations occurring in the Notch1 gene, could even enhance the prosurvival signals that the normal pathway already confers to CLL cells interacting reciprocally or with BM stromal cells.
According to this latter definition, the role of the formal organizational structure seems to emerge as a relevant predictor in the creation of interconnections: actors who belong to the same organization are more likely to interact reciprocally, because they have similar problems they need to share and solve.
The models were implemented in MATLAB-Simulink®, where they interacted to reciprocally provide information.
As different compartments interact and reciprocally transmit compartment pressures, the concept of polycompartment syndrome is suggested [39].
As different compartments interact and reciprocally transmit compartment pressures, the concept of polycompartment syndrome is suggested [ 39].
