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In our experiments we use a dataset of 23 known RNA-RNA interactions which contains two recently compiled test sets.
Similarly the redundancy score is 0.1523 out of 170 genes (in Supplementary Dataset 6) for DEG + ellipsoidFN, and 0.1652 out of 90 genes and 38 interactions which contains 135 genes (in Supplementary Dataset 5) for PPIA + ellipsoidFN method.
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In the experiment, the target genes were detected by TargetScan, and then the target proteins with the target genes regulated by certain miRNAs were collected as a sub-network L0, and all the interactions which contain target proteins were collected as sub-network L1.
Our method has more difficulties with set two for the handshake interaction, which contains more occlusions when people walk behind each other.
Graphene-coated surfaces have been reported to allow a high adsorption of serum proteins (due to π-electron interaction), which contain extracellular matrix proteins (e.g., albumin, fibronectin, vitronectin); this may explain the cellular behavior on the graphene-coated samples and suggests a similar profile of protein adsorption [21, 23].
In our previous work, we have integrated a set of human protein-protein interaction data and transcriptional regulatory interaction data, which contains 37811 experimentally confirmed protein-protein interactions and 9148 experimentally confirmed transcriptional regulatory interactions [16].
To validate the universality of our analytic results, we use the other yeast protein interaction dataset which contains 12051 non-self interactions between 3264 proteins.
These are given by combinations of certain TF concentrations, resulting from the dynamics of the interaction network, which contains several positive and negative feedback loops.
In particular, the Systems Biology Ontology (SBO), which is closely integrated into SBML, contains an "interaction" branch, which contains terms such as phosphorylation (SBO 0000216), a sub-term of the "Addition of chemical group" term (SBO 0000210).
Knowledge is provided in form of an interaction matrix which contains values assigned to particular connections, coded in the following way: no connection (0), activation (10), inhibition (-10), activation or inhibition (1) or not available (NA).
Members of the NLR family share common structural and functional similarities with the TLRs, which include a carboxyl-terminal LRR; a central nucleotide binding domain (NACHT) domain, which has intrinsic ATPase activity; and an amino-terminal protein-protein interaction domain, which contains either a caspase activation and recruitment (CARD) domain or a baculovirus inhibitory repeat domain [ 12].
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