Our data strongly suggest that SR protein RS-domain-mediated protein-protein interactions are not required for SR proteins to promote recruitment of other splicing factors.
Our results demonstrate that BRCT-dependent interactions are not required for PAR/mADPR accumulation, suggesting that DNA repair complex formation and mADPR generation functions are at least parallel, and possibly independent.
However, even this early study showed "B b" interactions were not required.
Thus, like the "B b" interactions, the αC:αC interactions were not required for the assembly of protofibrils.
Aromatic aromatic interactions are not required for IAPP amyloid formation, although their removal does slow the process.
This indicates that T cell receptor/MHC interactions are not required for the abnormally increased death of CAML-deficient pre-T cells.
When compared to MC methods, the use of D-LBTE solvers might result in relatively shorter calculation time as explicit modeling of a large number of particle interactions is not required.
While our data does not provide evidence for or against an interaction between the S2 region of myosin and cMyBP-C, it does show that such interactions are not required for the activation of the thin filament by cMyBP-C N-terminal domains, as observed in this work.
Interestingly, blocking mAbs against ICAM-1 or ICAM-2 are only effective when placed on the basal side of the intercellular junctions, implying that, although LFA-1/ICAM-1 and ICAM-2 interactions are not required for adhesion to the basal surface of the epithelium, they are required in a postadhesion step prior to diapedesis.
As such, we have performed the experiment suggested by the reviewer and compared 200 nm particle induction of Tfh cells in C57BL/6 and MD4 BcR transgenic mice (i.e. in the absence of cognate B cell interactions), and these studies show these cognate interactions were not required.
