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Overall, we conclude virus:α9β1 interactions to play a key role in trafficking of KSHV via endosomes to eventually escape into the cytoplasm.
The endocrine system focuses on ligand-receptor interactions to play a critical role in growth and development of multicellular eukaryotes [ 3, 4].
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Background & Aims: Dysregulated host/microbial interactions appear to play a central role in the development of inflammatory bowel disease (IBD).
With the increased dwell time of DNA in the pore, DNA-pore interactions begin to play an increasingly important role in translocation kinetics.
Collectively, the attachment of combinatorial peptides representing different signaling in ECM-cell interactions proved to play a key role, contributing to the formation of a functional cardiac muscle tissue, in vitro.
3D modeling revealed a hot spot area formed by 3 binding sites, forces including hydrogen bonds and van der Waals interactions appear to play a significant role in enabling and stabilizing the binding of chemicals.
For example, a customer could start by being engaged online looking at a Tweet, then go to your website, then look up reviews, then call for a demonstration or sign up for a trial... just look at how many interactions need to play together to keep them engaged and get them through to the next steps towards purchase.
Allosteric receptor interactions appear to play a role in this phenomenon.
Thus, as observed in prostate and gastric cancer [ 25, 26], MIF/CD74 interactions appear to play a role in breast tumourigenesis.
Relatively smaller structures such as nuclear pores, centrosomes and kinetochores are beginning to be characterized and, in each case, protein-protein interactions seem to play a crucial role.
Many researchers are focusing their efforts on epistasis and the community is beginning to discover epistatic interactions that play a role in Alzheimer's disease, but based on odds ratios none of the as-yet discovered interactions appear to play a significant role in Alzheimer's disease etiology.
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