Exact(1)
Under these conditions of widespread disruption of peptide/MHCII interactions, the probability of close approximation of the prebound and exchange peptides to a destabilized peptide binding groove is enhanced.
Similar(57)
Despite the increase in probability of being recognized through greater interaction, the probability of 'gain' would work out more than the 'loss' even though the value of goods was kept marginal.
The predicted probability model introduced in this paper helps in identifying distinctive interactions and the probability of their occurrence in the landscape.
Generally these interactions bias the probability of some action (e.g., change in state, new behaviour), which then occurs on a stochastic basis (Losick and Desplan, 2008).
Once these statistics are obtained for each pair of proteins, we compute the reliability of interaction as the probability of a true interaction between u and v given X (uv) = (X1 uv), X2 uv), X3 uv)), under the logistic distribution.
Previous workers have noted that in protein interaction networks, the probability of two genes being associated in a network is strongly correlated with the product of their individual node degrees (the number of connections they have) [53].
Associating each domain interaction with the probability of the corresponding edge between the connected proteins in the PPIN establishes an overall probability that can be used as an early pruning criterion.
Transmission of this type, although artificial in our case, is frequent in natural transmission of virus and other pathogens and the interaction between the probability of appearance of compensatory and reversion mutations, clonal interference and bottlenecks are likely to play a substantial role in the low reversibility at the sequence level.
We consider both options of minimizing the free energy of interaction and maximizing the probability of interaction while the interaction energy model introduced by [ 2] has been used.
For computing the interaction between accessible regions, IntaRNA minimizes the free energy of interaction and RNAup maximizes the probability of interaction while no internal base pair is allowed.
It has further been shown that protein interaction networks can be surprisingly accurately reconstructed by a model in which each gene i has an inherent and fixed probability pi of being an interactor, without any specificity in the interactions; in our model the probability of an interaction is determined only by the product of these probabilities.
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