Sentence examples for interactions target from inspiring English sources
For this simple approach to work, several fundamental conditions (nonspecific interactions, target site access, drug release and drug suitability) must be satisfied.
Finally, as most reported Mcm7 binding interactions target the Mcm7 C-terminus, competition among these factors for Mcm7 binding may be an important aspect of Mcm2-7 regulation.
Only eight out of 1,926 predicted interactions target mRNA within the selected 91 proteins and these are: CYP26B1: miR-d11, ILF3: miR-d10, MCL1: miR-d7, PAK2: miR-d3, miR-d7, miR-d8, SMAD7: miR-d12.
Network construction was divided into two components: miRNA-target interactions and target-target interactions.
miRNA-target interactions and target-target interactions were integrated to construct possible regulatory networks.
Changes in intracellular active drug concentrations, drug-target interactions, target-mediated cell damage, damage-induced cell death machineries or the signals from extracellular environments are actively at play under in vivo conditions.
For long-oligo microarrays, multi-state hybridization models must be used, that take into account factors such as probe folding, target folding, probe-probe interactions, target-target interactions, and competition between closely similar sequences [31], [32], [33].
In contrast, as sialidases may regulate multiple Siglec-TLR interactions, targeting host sialidase may be more effective.
†ENCODE 5C long range interactions targeted ~1% of the genome this coverage and expectations were derived based on this proportion, and 1% of the unique eSNP positions.
Thus, unlike nodes with many physical interactions, targeting functional hubs with drugs is more likely to maximize impact on the disease while minimizing effects on general physiological processes.
A comprehensive mapping of mosquito protein interactions targeted by DENV could provide specific hypotheses and a broad perspective on DENV strategies for replication and persistence in mosquitoes.
