Exact(1)
Our analysis indicates that inadequate statistical power, racial/ethnic differences in frequencies of alleles, haplotypes and haplotype combinations, potential gene-gene or gene-environment interactions, publication bias, and multiple hypothesis testing may contribute to the significant heterogeneity in previous studies of CAPN10 and T2D.
Similar(59)
Specifically, the association of stent thrombosis with loss of function genotypes was subject to bias from small study effects and to interaction with publication year.
Manual curation of chemical-gene interactions from publications is a very time-consuming process producing high-quality information but with limited coverage, reflected by the number of chemicals that Patel and Butte could create gene sets for (1338 chemicals).
> -wrap-foot> The ppiTrim algorithms work best if accurate and fully populated fields for interaction detection method, publication and interaction type are available in its input data set.
Based on co-occurring citations, that is, the interaction of publications as they refer to each other, we can see the dominance of STEM areas again, particularly engineering, natural science and medicine.
The regression model was specified to assess interactions of assumed publication year with all moderating variables, since significant interaction terms can be interpreted as differences of the slope due to moderating variables.
We extracted miRNA-target interactions from the publication of Wu et al. [ 23] where a list of predicted p21-regulating miRNAs was subjected to experimental validation.
The protein interactions from this publication have been submitted to the IMEx consortium (http://www.imexconsortium.org) through IntAct (PMID: 19850723) and assigned the identifier IM-18676.
To do so, we first constructed a p21 regulatory network using the following steps: We extracted miRNA-target interactions from the publication of Wu et al. [ 23 ] where a list of predicted p21-regulating miRNAs was subjected to experimental validation.
[The protein interactions from this publication have been submitted to the IMEx (http://www.imexconsortium.org) consortium through IntAct (PMID: 19850723) and assigned the identifier IM-14654] Because of its biological importance, the PDZ (PSD-95, Discs-large, ZO-1) domain has been intensively studied at the structural and functional level.
Here we quantify the agreement between curated interactions from 15 471 publications shared across nine major public databases.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com