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IGENT_stepwise took about 1.5 hour in higher order interactions on the same system.
The LR2 model is typically more variable since it in effect pays a penalty for having to estimate all the two-way interactions on the same sample.
In contrast, cis interactions (on the same cell surface) show no isoform specificity and can be mediated by either covalent disulphide bonding or noncovalent bonds.
The disease-based approach of VCM is particularly valuable, as it allows drugs to be presented according to the disease they treat; this in turn makes possible to organize drugs on the anatomical schema, and to represent contraindications and drug interactions on the same "Mister VCM".
In addition, when we considered interactions between ozone and temperature in the single-pollutant model, there was no significant interaction between ozone and temperature (p values of the interactions on the same day of a PCV, on the day before a PCV, and for 3-days mean were 0.17, 0.21 and 0.11, respectively); the association between ozone and PCV remained significant (data not shown).
Consequently, drug icons can be positioned on the anatomical axis and mixed with disease icons, and it is possible to represent contraindications and drug interactions on the same "Mister VCM" (in figure 2, "Mister VCM" displays both VCM icons for diseases, for example viral infection, and VCM icons for drugs, like antitumorals).
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The present study was undertaken to follow the effect of interaction of organic molecules with Cu+ sites on the properties of these Cu+ ions, as well as the effect of interaction with CO on the interaction of the same Cu+ with organic molecules.
Although we exclusively visualized staples resulting from trans-interactions (two opposed membranes), we cannot rule out that cis-interactions (on the same membrane) may occurs when the physical constraints are favorable.
The 11,500+ curated interactions can be grouped into 7,985 non-redundant interactions (based on the same participants and interaction type).
The magnitude of these interactions is on the same scale as the total free energy of folding, so that significant changes in can be caused by modifying only a few of these interactions.
Since these interactions depend on the same domain in Survivin, they are thought to be mutually exclusive, and it was proposed that Survivin binds to Shugoshin-1 before H3-T3 is phosphorylated.
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