In fact, several experiments, including crystallographic study, have documented the role of such molecules for correct interactions with human class I HLA molecules (Wesley et al, 1993; Sun et al, 1995; Gao et al, 1997).
In many cases the bond graphs of such molecules are not bipartite and the studies usually focus on isolated molecules, ignoring the intermolecular interactions, such as hydrogen bonds, found in crystals.
Even the design of such molecules is a daunting task, however, as they need to be able to use light, chemical or electrical energy to modulate their interaction with the surface in a way that generates directional motion.
It is already known that these interactions, under certain circumstances, may reflect non-specific interactions of biological molecules such as solubility, penetrance, and transport etc. [45] [50].
Network analysis can be used to identify genes in the same biological processes or pathways, to infer interactions of bio-molecules, such as their physical association, metabolite flow, regulatory relationships and co-expression relationships and so forth.
Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance.
These activities result from the behaviour and interaction of key molecules, such as Myosin, Actin, Microtubules, Cadherins, Integrins and Rab proteins.
Non-genetic intrinsic heterogeneity stems from the random (thermal) nature of interaction of individual molecules, such as mRNA and proteins.
An advantage of expressing both tetR-KRAB and rtTA2S-M2 is that the P tet is bound in the absence and presence of Dox and this will limit potential interaction of endogenous molecules such as GATA factors with the promoter [ 30].
These methods bring to focus the integrated nature and complex interactions of biological molecules and processes and, as such, define the emerging field of systems biology.
