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We have employed a 3D tissue engineered disease-like system to emulate cystic structures in vitro and analyzed the extracellular matrix (ECM) interactions in it.
Encapsulated microbes can grow only if the droplet localizes symbiotic interactions in it (Fig. 1a).
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The presence of disordered sequences in interacting domains can favour via the "fly-casting mechanism" protein protein interactions, in addition it favours an induced-fitting rather than a lock key type of interactions.
The measured distances amongst the three aromatic side chains varied from 3.2 Å to 5.1 Å (Fig. 5B) well positioned for hydrophobic bonding interactions in that it fits generally the criteria for defining a hydrophobic bond (interaction).
The degree of a protein in a graph is the number of interactions in which it participates.
Since HSP82 is a global modulator, the genetic interactions in which it participates only allow for weak function inferences.
The MBD is atypical of protein DNA interactions in that it displays nonlinear linkage.
Ideally, as cooperativity is intrinsic to molecular interactions in biology, it should be inherent to a molecular interaction standard.
Each entity in the network is annotated with a complete list of interactions in which it participates, and PMIDs supporting those interactions.
In the web-published diagram, each node is clickable and links to a complete list of interactions in which it is involved; interactions themselves are supported by hyperlinked PMIDs.
By the integration of CoryneRegNet services, for example, EMMA can now retrieve and depict information on the operon membership of a gene, and the annotated regulatory interactions in which it is involved (see Figure 3).
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CEO of Professional Science Editing for Scientists @ prosciediting.com