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We recently developed a general combinatorial approach, namely the generalized multifactor dimensionality reduction (GMDR) method, which can entertain both qualitative and quantitative phenotypes and allows for both discrete and continuous covariates to detect G × G and G × E interactions in a sample of unrelated individuals.
This study examined G × E interactions in a sample of children with Japanese pediatric depression to test the hypothesis that 5-HTTLPR is involved in the etiology of childhood depression.
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Moreover, few reports in the literature describe studies of G × E interaction in a sample of young people.
In a study with adolescent mothers, Cassidy, Zoccolillo and Hughes [ 13] found positive correlations between the severity of maternal depression and maternal control in dyadic interactions in a clinical sample, whereas the correlation with unresponsiveness was not significant.
Unfortunately, more advanced methods that could address both mediation and interaction concurrently (i.e., exposure-mediator interactions) in a complex sampling design such as NHANES are not readily available.
Some cases do not entail any interaction--a sample comes in, a test is run, and the results are reported.
Therefore, the overall aim of the current study is to estimate the prevalence of PIP/PPOs, particularly relating to drug-disease interactions, in a nationally representative sample of individuals aged ≥65 years, using a subset of the STOPP/START criteria.
A fourth study which tried to confirm the interaction in a Mexican sample revealed no association with ADHD, neither for the individual markers nor for their combination [ 59].
21 In the present study, we observed a gene-environment interaction in a population sample for the IL6-174C allele, with increased IL-6 levels and a consistent trend of increased MI risk after long-term traffic-NO2 exposure.
In general, such chips use immobilised proteins, peptides, lipids or small molecules to study the interaction of proteins in a sample.
Gene-environment interaction was studied in a sample of young (mean age 26 years, N = 385) and older (mean age 49 years, N = 370) adult males and females.
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