Hyperion is a spectacular exception to the rule in which tidal interactions force moons into synchronous rotation.
Specifically, the structure is shown to exhibit particularly interesting nonlinear behaviors, including jumps, modal interactions, force relaxation and chattering during impacts on the mechanical stops.
We apply this framework to conservation challenges and opportunities in the Arctic, where the rapid pace of human-induced changes and their interactions force us now to consider a new relationship between people and the rest of nature.
As shown in our studies of force dependent talin deformation and talin vinculin interactions, force dependent conformational changes of talin drastically affect its interaction with the vinculin head.
For most interactions, force acts to decrease the stability of the folded or bound state of a protein or complex relative to the unfolded or dissociated state.
It can flag up drug-drug interactions, force compliance with hospital protocols, and can prevent the prescription of certain drugs, thus implementing evidence based medicine [ 4] and improving clinical practice [ 5- 7].
