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The discovery has already begun challenging longstanding theory about how those interactions evolve.
What are the interactions of classical pathogenic bacteria with commensals and how do these interactions evolve to allow establishment of dominant infections at later disease stage?
Regulatory components and interactions evolve to adopt new configurations through mutations and network rewiring events, resulting in novel phenotypes that may benefit the cell.
But why did these interactions evolve?
Image credit: Noah Snyder-Mackler Why did social interactions evolve?
However, little is known about how stromal epithelial interactions evolve in benign and pre-invasive lesions.
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PPI networks have recently been introduced to extract subnetworks of interacting proteins or to identify deregulated molecular interactions, evolving from a pathway-based to a protein-network-based approach [18] [21].
Mentors stated that over time their interactions evolved into either a mutually rewarding friendship or a comfortable relationship within a learning community that valued collective learning.
Regulation of hemodynamic parameters is a challenging problem, due to inter- and intra-patient variability, drug interactions, evolving patient condition, and in the case of simultaneous control of mean arterial pressure and cardiac output, tight coupling between the two variables.
How and why these two different DNA-protein interactions evolved is unclear.
As shown in Figure 2C, in this case the initial dynamics driven by Notch-ligand short-range cell interactions evolves until it reaches a steady stage where Notch activation, Wg diffusive signaling, and Cut expression are self-sustained due to the interactions between boundary and non-boundary cells.
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