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The unique interactions established by the exon 5 motif are essential to the stability of the ATD/LBD and LBD/LBD interfaces that are critically involved in controlling proton sensitivity and deactivation.
The hydrogen bonding network and the π π stacking properties could be the key interactions established by the most active compounds that significantly contribute towards their activity profile.
It only considers the number of interactions established by a species within a network (i.e. its degree) and how those interactions differ among species.
The stable interactions established by LRP-1-ICD with ERK and JNK may influence the ability of MAPK to reach their downstream targets and may have a repercussion for spatial and temporal propagation of intracellular signaling.
The mutation abolished the ability of the peptide to acquire secondary structure in the presence of SDS micelles, as shown by Freitas et al. [12], suggesting that aromatic-aromatic interactions established by Trp8 and Phe12 are important in stabilizing a helical structure in the peptide [12].
In addition, the HX and UbdA mutations have distinct effects for the majority of interactions established by Ubx or AbdA.
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It adopts a helical structure in the presence of mimetic membranes that is stabilized by the presence of an aromatic-aromatic interaction established by Trp8 and Phe12.
Relevant roles are attributed to Gal-3 interactions established during infections (reviewed by ref. 31).
The rheological behaviour of these solutions was characterized and could be adequately explained by the interactions established during the formation of the IHNs, thus providing useful information for developing novel satiating ingredients.
Related to this, it has been shown that poliovirus fitness can be determined by cooperative interactions established among genotypes, thus making viral fitness an emergent property of the population rather than an individual property (Vignuzzi et al., 2006), and our results provide a structural and genetic basis for these observations.
Interspecies transmission between humans and pets might have been facilitated by the social interactions established since domestication of small carnivores.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com