Therefore only a preliminary conclusion about interaction can be drawn and it calls for a validation in future studies.
From the position of these amino acid residues in the 3D structure of PAI-1 and the effects of the corresponding monoclonal antibodies on t-PA-PAI-1 interaction, conclusions can be drawn with respect to this serpin-serine proteinase interaction.
Already, gene expression and proteomic profiles have been generated, mainly for cerebella (Liao et al., 2010; Cologna et al., 2012; Lopez et al., 2012b; Lopez et al., 2012a; Sleat et al., 2012), and a rudimentary schematic of cellular and molecular interactions in vivo can be drawn (Fig. 4A).
To our knowledge, this is the first study to suggest such an interaction, and it remains for future studies to further define this linkage block and replicate the interaction before any conclusions can be drawn.
Another supporting evidence for such converging interaction upon the NMDA receptor can be drawn from the resemblance of the two ERK2 activation kinetics patterns: the low doses co-application of NMDA and dopamine and that of the NMDA high dose application.
These conflicting patterns of interaction specificity indicate that further work is necessary before any general conclusions about interaction specificity at lower taxonomic levels can be drawn.
Both studies identified some differences in the processes of writing in different modes, but no conclusions can be drawn on the interaction between contextual features and test takers' ability to write on the computer.
It is important to note that the tests for interaction were not statistically significant; therefore, no firm conclusions can be drawn from these subgroup analyses.
Regarding the effect of CDP-choline on leukocyte-endothel interactions and microcirculatory alterations in this study, no final conclusion can be drawn necessitating further studies.
These interactions have to be replicated in other prospective studies before conclusions regarding biological mechanisms can be drawn.
