Sentence examples for interactions between mutants from inspiring English sources

We also noted genetic interactions between mutants in the TORC1 pathway and GLC7 mutants that suppress ipl1 -2.

We have previously shown that tbx-2 gene transcription is directly repressed by the NF-Y transcription factor, and strong genetic interactions between mutants affecting NF-Y and tbx-2 (bx59 ) indicate this repression is crucial for tbx-2 function in vivo (Milton et al. 2013).

We discuss interactions between mutant IDH1/2 inhibitors and conventional therapies.

To investigate the mechanisms of lens opacity formation in the knock-in lenses, we assessed the interactions between mutant αB-crystallin and vimentin.

Therefore, we hypothesized that the interactions between mutant huntingtin, CaM and TG may be deleterious.

Fig. 4 summarizes reciprocal tests for interactions between mutant and wild-type receptors in the trypsin digestion assay.

The interactions between mutant P53 and ER have been suggested to play a potential role in mammary tissue homeostasis and cancer formation.

We therefore suggest that blocking interactions between mutant polyQ proteins and their CC partners might constitute a promising preventive strategy against neurodegeneration.

Aberrant interactions between mutant huntingtin, or its proteolytic fragments, and many other proteins, as well as downstream effects have been identified, which collectively play roles in neurodegeneration and which have become therapeutic targets for disease modification.

However, using a panel of fluorescently tagged variants of SOD1 in a cell model of mutant SOD1 aggregation, we demonstrate that the interactions between mutant and WT SOD1 in aggregate formation are not simply a co-assembly of mutant and WT proteins.

More formally, a genetic interaction between mutants i and j can be defined by the deviation (εij) of an observed double-mutant phenotype (Pij) from the expected neutral phenotype of an organism's fitness (Eij) under the hypothesis that it carries two non-interacting mutations (the null hypothesis).