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Unlike biophysical models, 'molecular' models rely on known molecular interactions and rate constants to simulate spindle checkpoint signalling.
Most of these kinetic models can not consider dynamic change in properties of substrate (accessibility of enzymes) that directly affect the enzyme-substrate interactions and rate of hydrolysis in detail.
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However, overcoming differences among model predictions [26] and discrepancies between fundamental and realized niches [27] usually requires detailed data on species migration rates, interspecies interactions, and rates of adaptation [28].
When investigating the quality of parent child interaction, videotaped interactions and rating scales may give more detailed information about the various aspects of parent child interactions [ 12, 13].
Stapled versions of 6K-F17 showed an increase in non-selective membrane interaction, where the staple itself enhances the degree of membrane interaction and rate of cell death while maintaining high potency against bacterial membranes.
Before dividing the dataset into quantiles according to expression level, we measured the strength of the correlation between number of interactions and evolutionary rate for all 555 genes for which we had interaction, evolutionary rate, and expression data.
Second, current results do not indicate that the correlation between interactions and evolutionary rate is entirely due to the association between expression and evolutionary rate.
Thus, the model considers molecular flexibility, intermolecular interactions and test rate, which makes it a reliable and interpretable subset.
Based on this observation, they conclude that the relationship between interactions and evolutionary rate does not apply to bacteria.
Only a very weak negative correlation between the number of interactions and evolutionary rate of a protein was observed.
In every bin, the correlation between number of interactions and evolutionary rate is significant, even after controlling for expression levels.
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