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One SNP (rs13281615 in 8q4) first described by Easton et al. [ 1] showed a weak tendency for interaction with use of HRT.
However, previous studies have indicated that alcohol consumption is either weakly or not associated with a reduced risk of endometrial cancer and no significant interaction with use of HRT has been found [ 9].
Because SNPs selected for this study were previously found to have a potential multiplicative statistical interaction with use of MHT on breast cancer risk, we evaluated whether interactions on mammographic density differed for cases and non-cases by entering a three-way interaction term (SNP × MHT × case status) into multiple regression models.
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Layers of lignin were reduced which led to an improvement of the interaction with used epoxy resin.
However, the four genome-wide gene-environment interaction studies on which we partly based our SNP selection also investigated solely interactions with use of any MHT.
These findings add to data from other countries that showed a correlation between positive client-provider interactions with use of communication tools and enhanced client satisfaction, increased knowledge levels, and longer and more effective use of methods.
We could therefore not investigate interactions with use of combined estrogen-progesterone therapies, which seem to be more strongly associated with an increased mammographic density than estrogen-only therapies [ 16, 17].
However, few studies have examined this association by HT use or tested the interaction with hormone use.
Only the use of vitamin D3 showed an interaction with prednisone use.
However, three SNPs in PLCG2 showing potential interaction with MHT use for overall breast cancer risk in our previous study also showed potential interactions with MHT use for mammographic density in this study, but solely among cases.
Sex was a factor in middle adolescence as an interaction with the use of birth control.
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