This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme.
However, conformational information regarding their interaction with the target enzyme trypanothione reductase has yet to be obtained.
Our goal is to modify the P3 site of this motif in order to identify the structural requirements for the interaction with the target.
In fact, a hydrophilic and cell-repelling delivery system is not always beneficial, as it might decrease the interaction with the target cell and hinder drug release.
Moreover, the enhancement in fluorescence upon interaction with the target nucleotide constitutes a favourable approach towards the detection of cGMP in buffered media.
These results indicated that stapling of the free peptide in the scaffold increases the favorable enthalpy of the interaction with the target protein.
Purvalanol, revealed a good binding affinity (− 29.78) and residues involved in interaction are ASP208, Arg243, His236 and Lys237 forming hydrogen bonds, which signifies the presence of strong interaction with the target protein.
The improved sensing response characteristics of the heterointerface sensor structure are attributed to formation of p n junctions at the interface of SnO2 with TeO2 microdiscs and modulation of the depletion width on interaction with the target NO2 gas.
On the basis of the photocatalytic data illustrated in this paper, the presence of such species at the surface was not detrimental for the photocatalytic activity of nitrogen doped TiO2 but actually contributed to a higher interaction with the target cyanotoxin; leading to a higher photocatalytic activity than that observed for samples prepared via the classic sol gel method.
Future applications could include the use of other types of fluorescent probes, in particular, those that are activated only after interaction with the target for the monitoring of a variety of tumor-related molecules [8].
Once a chemical is found to have suitable properties, it can be used as a lead or reference to develop analogs that will further enhance the potency and selectivity for interaction with the target.
