Exact(20)
Cytoscape [ 55] was employed to generate protein metabolite networks using the edge-weighted force-directed layout based on interaction weight.
With recent updates to EdgeRank, Facebook's proprietary content-ranking algorithm, your post's visibility is a function of affinity (how close you are to your friend, as measured by past interaction), weight (how many comments and likes your post received), and time decay (how recently you posted).
Compared to the network from untreated patients, Jagged1 therapy induced an increase in the interaction weight between JAG1-TNF and the downstream interaction TNF-IFNG, as well as a decrease in the interaction weight between CD28-TNF (Figure 4A).
In addition, the validation of new gene interactions indicates that differences in gene interaction weight have biological implications, at least at the gene expression level.
Following the same procedure, we reconstructed the T-cell activation network using the gene expression levels from IFN-ß treated and untreated patients, and we compared the differences in interaction weight between pairs of genes (Figure 3B).
While we identified the immunomodulatory effect of IFN-ß therapy in the T-cell activation network, we found that it did not restore their interaction weight to the baseline levels represented by the HC network (Figure 3C).
Similar(38)
These interaction weights representing elements of S and D are denoted by s and d respectively.
The probability distributions of interaction weights measured using pairwise s, d, c values for this system are similar to those shown in Fig. 2 but the patterns are not identical.
By 2 months, VAS tended to have a beneficial effect on weight and head circumference when given with BCG but not when given without BCG (interaction: weight-for-age p = 0.07 and head circumference-for-age: p = 0.06).
Network inference in this linear model reduces to finding the non-zero interaction weights.
This feature is strongly related to the network topology as well as the interaction weights.
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