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With the exception of the diet × θ interaction, we removed all non-significant interaction terms from the final model.
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In order to avoid trivially biasing our results toward a greater number of client interactions, we removed all interactions involving GroEL/GroES from the data set.
Due to the difficulty in detecting 0-duration calls which express significant interactions, we remove these records from the dataset.
In order to investigate whether C. lunatus established an intimate relationship with potato leaf in CDB medium during interaction, we aseptically removed intact leaf pieces from the reaction flask after 2 weeks of inoculation.
To ensure the interaction preference among proteins of a similar age is not limited to abundant proteins and thus not representative of the underlying complete interaction network, we remove the 10, 50, 100, 500 and 1000 most abundant proteins and recalculate ΔD.
In the absence of data that provide a clearer picture of how DNA damage-dependent phosphorylation regulates this interaction, we suggest removing panels F and G from Figure 4 and their discussion from the manuscript.
We also did not find any effect using an interaction term modeling time in relation to maternal depression status so we removed the interaction term from the multivariate models.
We removed interactions involving miRNAs or genes that were not present in the expression data.
Once each of the gold standards was constructed, we removed interactions without statistically significant associations (in the observational data) according to Fisher's Z-test [ 23] at 5% FDR [ 24, 25].
For each HIV-1 protein, we removed an interaction type if it described less than six interactions.
We first tested for all main effects, 2 and 3-way interactions; we then removed any non-significant interaction terms (P > 0.05).
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