For polyglutamine diseases, including HD, such interactions are not reported.
Where available, consensus lists were searched against mouse data sets containing previously reported interaction data; however, in cases where interactions were not reported in mouse data sets, human orthologues were used to model potential interactions.
We include these genes here to provide a more complete picture of the observed difference in genetic susceptibility between men and women, and because formal genotype-gender interaction analysis was not reported for any of the genes in our previous publications.
Finally, FUS is present in a complex with SMN and the NFAR proteins (71), although a direct interaction between SMN and FUS was not reported.
Although the corresponding test of interaction between adherence level and effectiveness was not reported, the results of sub-group analysis were consistent with TFV gel being more effective among women with higher adherence (54, 38 and 28%% reductions in risk for women with greater than 80, 50 80 and less than 50 adherence, respectively).
These newly predicted ligands are cationic amines that mostly bind with μOR and show unique interactions of hydrogen bonding with Asp147, which was not reported before in the literature [13].
Therefore interaction results are not reported.
Thus, many resources attempt to improve coverage by inferring through computational approaches (e.g. phylogenetic profiling, association methods, inference of interactions from homologous structures) those interactions that are not reported in the literature.
The construction of negative training sets for protein interaction prediction is a notorious problem [10], [38], because many interactions that are not reported in the databases may actually be true positives due to our incomplete knowledge.
Tests for the statistical significance of interactions, though, are not reported.
