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Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into the hydrophobic back pocket.
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Biomolecule material interaction is accomplished via molecular specificity, leading to the formation of controlled structures and functions at all scales of dimensional hierarchy.
It is unknown at what subcellular location this crucial step of signal initiation occurs and how the enzyme substrate interaction is accomplished.
Ours and others, data indicate that in the case of F2A this interaction with the tunnel occurs along the entire length of F2A, whereas in the case of T2A it appears that the net effect of this tunnel interaction is accomplished by a shorter tract.
Visualization of interactions was accomplished using conditioning plots (Fig. 1).
However, mapping of disease phenotypes to alterations of these networks of interactions is accomplished indirectly and non-systematically.
In an organism, such dynamic rewiring of molecular interactions is accomplished by regulating gene expression.
Further, validation of the interaction studies was accomplished by carrying out molecular docking studies with DNA, RNA and Topo-II targets.
Interaction analysis was accomplished using STRING 9.1 [ 27] using a medium confidence setting and the Experiment and Databases prediction methods.
Biological characterization of the data, selection of cancer markers, and identification of protein interaction networks was accomplished with a combination of bioinformatics tools provided by GoMiner, DAVID and STRING.
Design of interaction entropy graphs was accomplished using the Orange software [ 75].
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