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Value of α is varied between zero and one until we get stabilized interaction values for 10000 interactions.
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Because the treatment-by-trial phase interaction value for the primary end point was nonsignificant (P=0.428), the 2 trial phases were pooled for all analyses.
Interaction values selected for clustering represented the union of genes from the yor1-ΔF670/R1116T screen with interaction values >10 or <-16 and the screen with wild-type YOR1 in the same background with interaction values >10 or <-12.
However, because of the multiple comparisons and the post hoc nature of these analyses, the interaction P values for A1C and aspirin use should only be considered suggestive.
In the fully adjusted model, there was no apparent age & sex interaction (p-value for interaction = 0.12).
The observed pattern suggested additive effects of the two polymorphisms and there was no statistically significant interaction (P-value for interaction = 0.19).
Additional interaction (p value for excluding interaction from model = 0.002) between marital status and sex indicated that the high HIV prevalence in single TB patients was mainly attributable to HIV infection among male patients.
Interaction terms were largely nonsignificant, though there was evidence of differences by sex (interaction p-value for copper = 0.03, zinc = 0.006) for inflammation scores.
We did not observe study heterogeneity for this interaction (P value for heterogeneity = 0.75, I = 0 %).
However, the interaction p-value for PEF analyses was not significant after correction for multiple tests.
We used the FDR method to adjust interaction p-values for multiple comparisons.
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