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Topological models propose that insulators are vital for establishing discrete structural loops that restrict the possibility of enhancer promoter interaction to those elements within the domain.
The change in this interaction can be attributed to the bulkier nature of the ester substituent since a similar packing arrangement and associated pairwise O···H interaction to those observed for 1– 3 would result in large void spaces throughout the molecule.
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Greater sophistication is emerging in other areas of gaming too, as technology frees the medium from having to limit character interactions to those involving live ammunition.
Studies range from those investigating aspects of the ecology of edaphically specialized plant populations and plant plant interactions to those exploring factors and mechanisms driving the assembly of plant communities (see Harrison and Rajakaruna 2011).
A comparison of the circular-dichroism and fluorescence spectra of the purified chimera and the SH3 circular permutant showed that the proline-rich sequence occupies the putative SH3 binding site in a similar conformation and with comparable interactions to those found in complexes between SH3 and proline-rich peptides.
Although Tarbase does not represent a non-biased list of microRNA targets, it is interesting to compare our list of 2+DB microRNA interactions to those present in their database.
For this purpose, we compared low-frequency normal modes calculated for a model with full interactions to those for a model without specific interactions.
Reducing p300 function might be predicted to shift TF interactions to those with CBP as is argued for β-catenin, and this in turn would favor an expansion of non-differentiated (and perhaps) stem and progenitor cells.
There are several reasons that might account for this: we have constructed an extremely parsimonious model, limiting the interactions to those between phagocytes and bacteria as this appears to capture the essential dynamics.
Similarly, compounds 16 and 17 do not appear capable of making comparable interactions to those observed in X-ray structures suggesting that they might adopt different binding site poses related to these substitutions.
Interestingly when we examined the effect of the elg1 Δ mutation, part of an alternative RLC, we saw a very different (opposite) pattern of interactions to those seem by ctf8 Δ, ctf18 Δ, and dcc1 Δ mutations.
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