Sentence examples for interaction targets from inspiring English sources

Therefore, we may consider TTD as a subset of DrugBank, in which TTD only includes pharmacological targets, and DrugBank includes more comprehensive interaction targets.

Structure-based design approaches have also been successfully applied to the protein protein interaction targets p53 MDM2 and the Bcl-2 family.

Several advances in the fields of crystallography, molecular modeling, biophysical assays and chemistry are converging to making protein protein interaction targets more amenable to drug design.

Although no direct interaction targets, HIV dependent factor proteins also provide such a proteomic characteristics that are indirectly exploited by the virus.

Nevertheless, important progress has been made in discovering small molecular inhibitors of several important protein-protein interaction targets, such as MDM2-p53, BCL-XL-BAK and IL2-ILR [3], [36].

The problem can be solved at various levels of resolution ranging from identifying high level processes where a given protein might be associated with, to discovery of the cell specific protein-ligand interaction targets of a protein in different biological conditions.

Furthermore, vaccines can be formulated within particulate delivery systems, allowing for enhanced interaction, targeting, and uptake with antigen presenting cells and initiating an enhanced immune response.

For this simple approach to work, several fundamental conditions (nonspecific interactions, target site access, drug release and drug suitability) must be satisfied.

For long-oligo microarrays, multi-state hybridization models must be used, that take into account factors such as probe folding, target folding, probe-probe interactions, target-target interactions, and competition between closely similar sequences [31], [32], [33].

In contrast, as sialidases may regulate multiple Siglec-TLR interactions, targeting host sialidase may be more effective.

†ENCODE 5C long range interactions targeted ~1% of the genome this coverage and expectations were derived based on this proportion, and 1% of the unique eSNP positions.