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The protein protein interaction spectrum of WSA206 comprises 40% of those MADS and non-MADS-box proteins implicated in floral/anther expression and embryogenesis.
In this paper, we present a method called SimBoost that predicts continuous (non-binary) values of binding affinities of compounds and proteins and thus incorporates the whole interaction spectrum from true negative to true positive interactions.
As pointed out in [4], drawbacks of the binary problem formulation are that true-negative interactions and untested drug target pairs are not differentiated, and that the whole interaction spectrum, including both true-positive and true-negative interactions, is not covered well.
Mutualistic and parasitic networks are on opposite ends of the interaction spectrum in terms of the relationship of the participants (from +/+ to +/−), and nonetheless they appear to share a similar network structure.
Of note, vatalanib was generally well tolerated, which is in line with its narrow kinase interaction spectrum.
Vatalanib is active despite its narrow kinome interaction spectrum in patients diagnosed with imatinib-resistant GIST or with imatinib and sunitinib-resistant GIST.
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Systematic study on the interaction spectra of inhibitors with multiple human GPCRs will shed light on how to design the inhibitors for different diseases which are related to GPCRs.
Advanced GBA approaches, such as clustering genes based on correlated interaction spectra across multiple interaction partners (Carter et al. 2009; Collins et al. 2007; Costanzo et al. 2010; Drees et al. 2005; Segre et al. 2005), have successfully mapped genetic architecture on a large scale.
To examine possible protein protein interactions, spectra of hPPARα (0.42 μM), hGR (0.40 μM), hLXRα (0.44 μM), 0.21 μM hPPARα with 0.22 μM hLXRα, and 0.21 μM hPPARα with 0.20 μM hGR (the final amino acid molarity in each sample was equal to 0.0002 M) were recorded in 0.5 mM HEPES (pH 8.0), 5 μM EDTA, 5 mM KCl, and 0.04% glycerol at 23 °C in a 1 mm cuvette.
In this paper, from the perspective of individual interest optimization, we focus on strategy adaptation of network users and their interaction in spectrum trading process.
Reliable tip-sample interaction force spectrum is obtained for thin PS film with a thickness of 93 nm under different temperatures, as shown in Fig. 4.
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