The two other motif classes (NNP: a positive interaction spanned by two negative interactions, and NPP: a negative spanned by two positives) showed very distinct functional associations, with physical interactions dominating for the former but alternative enrichments, typical of biochemical pathways, dominating for the latter.
In five spontaneous interactions spanning an hour, Ms. Anderson offered simple electric-violin figurations and melodic sketches, often electronically altered and accompanied with sounds from two tiny keyboards.
The customer journey in today's digital world is complex, with interactions spanning many different applications, data sources and devices.
We identify that BanLec recognizes a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains.
Additional stabilisation is afforded by a combination of interactions spanning the S1, S2, S1′ and S2′ sub-sites of Cathepsin B. The greater experimental inhibitory activity of 3 compared with analogues is rationalised by the additional interactions formed between 3′ and the His110 and His111 residues in the occluding loop, which serve to hinder the entrance to the active site.
The widely diverse affinities reported for PDZ domain-peptide interactions, spanning more than three orders of magnitude, represent another source of confusion.
Aging is characterized by marked declines in sensory and cognitive functions [1] [4], and a vast literature implicates such age-related changes to co-occur not only with differences in functionally localized cortical activity [5] [8], but additionally in disrupted functional interactions spanning distributed, complex brain networks [9] [12].
The prior information network contains 154 interactions spanning multiple pathways.
Minor comment: The database contains over 500 million interactions spanning 8 organisms: A.
A crucial milestone to understand and control cellular behavior is the building up of reliable reconstructions of the interactions spanning different functional levels.
