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In the present study, the gene-environment iNteraction simulator (GENS2) has been used to simulate interactions through two genetic and one environmental factor which permit, also, for study the same effect on epistatic interactions.
Here, an automated package-device interaction simulator has been developed.
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We have simulated interactions among two genetic and one environmental factor using the Gene-Environment iNteraction Simulator 2 (GENS2).
DPL: disease-predisposing locus; GENS: Gene-Environment iNteraction Simulator; GxE: gene-environment interaction; KAPS: Knowledge-Aided Parameterization System; LD: linkage disequilibrium; MLM: Multi-Logistic Model.
This is why the authors [ 4] focused on a version of MLM with only one genetic factor and one environmental factor (giving only six parameters), which they implemented in Matlab in their program Gene-Environment iNteraction Simulator (GENS).
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The methodology uses C-based interaction between simulators.
ProtNet [ 12] is a cell automaton that permits the simulation and analysis the dynamic interactions occurring in a cell lattice under a set of interaction rules The simulator iterates for a number of time steps following the interaction rules contained in an input graph in which the edges link interacting proteins.
TraSMAPI is a Traffic Simulation Manager API, designed to provide real-time interaction with traffic simulators.
In Figure 2 is shown the simulators interaction.
Some auxiliary data structures, necessary to model the interaction among the simulators of different CIs, have been defined and have been populated through suitable queries to the KBS.
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