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Rual et al. [ 4] extracted a core interaction set of PPIs mentioned in more than one item of literature (e.g. journal article).
The overlapping score OS Pc, Kc) between a predicted overlapping structure Pc and a known complex Kc is calculated by the following formula: (4) where i is the size of the interaction set of the predicted overlapping structure and the known complex, |V Pc| is the size of the predicted overlapping structure and | V Kc| is the size of the known complex.
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The additional interactions are included only to allow for a comparison of interaction sets of equal size.
In particular, we utilized three protein interaction sets of the organisms S. cerevisiae [ 16], D. melanogaster [ 17] and H. sapiens [ 23, 24].
Applied to the evaluated protein interaction sets of S. cerevisae and D. melanogaster, we observe a strong and significant correlation between an interactions confidence and the expectation value of the underlying highest scoring domain interaction.
We used Tarbase V5.0 [63] to compare our 2+DB interaction set to the best curated set of microRNA interactions existing.
We found a large proportion of our interaction set to comprise novel interactions.
An interesting property of this interaction set is the inclusion of an antiparallel partner.
Re-analysis of the multi-parametric genetic interaction data set of Horn et al. (2010), a square matrix of all pairwise combinations of 93 genes.
Interactions between set of SNPs and physical characteristics like age and weight was identified (Fig 4A,B).
We examined the correlation between evolutionary rate and the number of protein protein interactions for sets of interactions determined by seven different high-throughput methods in Saccharomyces cerevisiae.
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