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This result suggests that network aligners such as L-GRAAL can be used as alternative protein interaction predictors.
Furthermore, functional interaction predictors have been more studied for other species such as worm and yeast, but received less attention for human.
To make a fair comparison, we were interested in functional interaction predictors; therefore, methods specifically designed for "direct" protein interactions such as tools using molecular docking or protein structural similarity were not considered.
We showed that GAP has a superior positive predictive value (i.e., precision rate), and specificity vs. sensitivity (i.e., true positive vs. true negative rates) in identifying known interactions as compared to the existing interaction predictors.
Data from the Causes of Death Register were used to test for mortality differences related to group interaction predictors such as age, inpatient versus outpatient status at intake and 2-year drinking outcome.
Auditory, visual, and interaction predictors could be alternatively described as an approximation of the 3 Fourier coefficients of the time courses in the audiovisual interaction representation frequency, and the auditory and visual stimulus representation frequencies (Hertz and Amedi 2010).
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After constructing the drug-target interaction predictor, we have to evaluate its performance.
We constructed two databases, named Rice Heat Shock Proteins (RiceHsps) and Rice Gene Expression Profile (RGEP), and one online tool, named Protein-Protein Interaction Predictor (PPIP).
Odds ratio (OR) estimates are presented for a one count per minute increase in each interaction predictor.
Re-analysing this interaction model with centred variables or with a residualized interaction term would reduce multi-colinearity between the main predictors and the interaction predictor, but would not change the interpretation of the results (Wu and Zumbo, 2008).
Rows i-l refer to results of Cox regression analyses for the interaction predictor variables shown in the presence of all the above predictor variables (data not shown for clarity and brevity).
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