Sentence examples for interaction of variants in from inspiring English sources

In particular, we searched for evidence of interaction of variants in these genes with two measures of early growth, one with indicators for potentially disturbed neurobehavioural development (measure of early development) and the other with risk factors from social environment for normal emotional development (measure of social environment).

For the interaction analysis of variants in the CHRNA5/A3/B4 region, both logistic regression and generalized multifactor dimensionality reduction (GMDR) analyses [36] were performed for binary traits (SI-1 and SC), whereas the cumulative logit model was applied to the ordinal phenotypes (SI-2 and SQ).

On the other site, interaction of multiple variants in different genes can provoke or aggravate a phenotype as well.

Many current methods address this problem by using a two stage procedure where they identify a subset of variants associated with disease in a univariate fashion in the first stage, and then evaluate interactions only within this smaller set of variants in the second stage [ 2].

clinical interpretation of variants in cancer.

The potential interaction of R72P variants with germline variants in other key regulators or effectors of the p53 pathway that may modify MDS risk and lenalidomide response merit further investigation in a larger cohort of patients.

However, our preliminary analyses show no evidence of interaction between variants in ADH1C and maternal alcohol consumption (results not shown).

Insulin resistance related genetic variants were associated with T2DM only in obese population while insulin secretory variants conferred a greater T2DM risk only in nonobese individuals, suggesting potential interaction of these variants with obesity status in T2DM occurrence [ 24].

The additional samples not reported in the initial manuscript show an interaction of CRHR1 variants and child abuse in the same direction, but less pronounced than in the first sample.

Approximately half of these interactions involved variants in the solute-carrier genes (7 interactions) and TGFB3 gene (5 interactions).

Therefore, we hypothesized that the interaction of genetic variants and DNA methylation in at least some of the genes in the Th2 pathway (IL4, IL4R, IL13, GATA3, and STAT6) would be associated with the risk of asthma, while SNPs may be a confounder for the main effect of DNA methylation in some genes.