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GNP assembly and disassembly concept was utilized for the study of molecular level interaction of these molecules.
The non-covalent interaction of these molecules with DNA duplexes have been investigated by ESI-MS technique.
This evidence can be explained by considering the strong interaction of these molecules with the TiO2 surface.
The high [DNA]/[compound] ratio needed for total binding, together with the negligible changes observed in absorption spectra (not shown), point to a weak interaction of these molecules with the nucleic acid.
An overview of the main biological techniques and approaches for testing the interaction of these molecules with the biological environment, mainly DNA, to validate the effect is also provided.
Here, for the first time, we determine the interaction of these molecules with hydroxyapatites, in view of establishing (i) how benzoxaborole drugs may adsorb onto biological apatites, as this could impact on their bioavailability, and (ii) how apatite-based materials can be used for their formulation.
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Since these compounds were active against PfTrxR as well, molecular docking was used to study their interactions with PfTrxR to gain further insight into the mode of interaction for these molecules.
In silico interactions of these molecules with chorismate mutase are also presented.
Structural studies over the last 10 years have provided a great deal of information regarding the complex interactions of these molecules with their receptors.
Here, we investigated nitric oxide and cytokine production and interactions of these molecules in MAM-stimulated co-cultures of macrophages (J774A.1 cell line) with spleen lymphocytes.
An attempt has been made to understand the mechanism of action by binding interactions of these molecules with β-ketoacyl-ACP synthase protein through docking studies.
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