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We did not expect complete protection from apoptosis of cells treated with Meso-TR3, even assuming 100%MUC166 blockade with soluble mesothelin, since all TRAIL variants (including TR3, recombinant rTRAIL and Meso-TR3) exhibit baseline apoptosis-inducing activities in MUC16-deficent cancer cells due to direct interaction of the TRAIL timer with cell surface DR4/5.
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This is especially clear in the interaction on the Trails A test (figure 3).
The simulations thus support the idea that in the ATP concentration range used in the experiments, the differences in the interactions of the trailing and leading ends of the myofilament with actin can generate compressive forces on the actin filament, and that these forces are sufficiently high to bend and break the actin filament.
After the interaction of TRAIL with DR4 or DR5, the signals are transmitted into the cells through the functional cytoplasmic death domain which lead to the transformation of procaspase-8 into caspase-8 [ 1].
And the other great benefit of digital information — whether in products themselves or merely in our online interactions — is the trail of data it leaves behind.
However, the general mechanism of the positive interaction of TRAIL with irradiation remains unclear.
Exons 4 and 5 encode for the amino acids in the extracellular domain that are responsible for the interaction of TRAIL with its receptors.
A specific analysis is carried out to detect noise sources on the blade surface, showing that broadband noise from 0.4 to 2 kHz is mainly due to the boundary layer scattering at the trailing edge and to the interaction of the tip vortex with the blade trailing edge, resulting rather non-sensitive to the inflow turbulence.
The preference of ants for less deviating paths, and the interaction of pheromone trails with this preference, should have consequences for colony-level path selection, allowing ant colonies to efficiently choose shorter paths to food sources (Garnier et al. 2013; Vela-Pérez et al. 2013).
To assess the interaction between the trailing ends of a sterilization micro-insert extending into the uterine cavity and the surrounding uterine tissue environment over time.
The enzyme can relieve this stress either by releasing the DNA to the downstream side, aborting transcript synthesis, and returning to the RPo, or by releasing the DNA to the upstream side, breaking the interactions of its trailing edge with the DNA, and escaping from the promoter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com