The effect of query interaction on the original graph structure is captured by change in GE (i.e. Δ GE c, t)), given similarly like equation (8).
The Leu93Val germline change is a conservative mutation that would preserve local interactions of the original Fr Leu residue.
By restricting this to interactions within the BT-409 complexes, we obtained 9918 interactions (15.8% of the original set).
It is worth noting that the particle size of AX-DOX is more uniform than AX because the formation of hydrogen bond and hydrophobic interaction changes the original configuration of AX, prevents the aggregation, and promotes more uniform distribution.
In order to obtain better precision it is possible to take into account the syntactic structure of the sentence, or the global distribution of interactions in the original database.
We compared our approach to a randomized PPI network constructed using the same number of interactions as the original PPI network.
The statistical significance of measured network parameters (e.g., number of observed interactions involving proteins with the same ancestry) was assessed on the basis of 10,000 randomized networks, each with the same nodes and the same number of interactions as the original one.
McKeown-Eyssen is particularly cautious about this finding because the analysis for such an interaction was not part of the original study design.
For improved reliability assessment, this version combines a new score derived from the experimental information of the interactions with the original score based on the features of the interacting proteins.
