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The general approach to co-enrollment was that all reasonable efforts should be made to minimize the exclusion of patients co-enrolled in another trial if they would likely represent those patients to whom trial results would possibly be applied in practice, as long as biologic interaction of the interventions being tested in the two trials seemed highly implausible.
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Results indicated a significant interaction of the intervention with left grip strength.
(More complex models of the effect of the intervention will include an interaction of the intervention with the temporal trend).
However, a test of the interaction of the intervention effect by glycemic status was not statistically significant.
'Mechanisms' are reactions, triggered by the interaction of the intervention and a certain context, which lead to change.
The results are representative of the interaction of the intervention arm (DA versus UC) by the gender groupings being conducted or not.
Though not labelled as such by the authors, they are in fact referring to mechanisms being triggered by the interaction of the intervention and the context.
Secondary, to assess the treatment effect over time, and the interaction of the intervention effect, we will use a mixed effects model.
This interaction of the intervention condition and age group was therefore significant for depression (DIKJ) and behaviour (CBCL) but not for the PTSS scores.
For all models the interaction of the intervention group and time period variable (baseline, 12 months and 24 months) was adjusted in order to take into account differences in MNA evolution between groups.
The analysis was first conducted as a simple main effects model, then any interaction of the intervention effect with age, sex, maternal baseline (P20, before start of supplementation) BMI, maternal baseline blood pressure (measured with Dinamap Pro 400, Critikon Ltd, United Kingdom), and child body composition was assessed by fitting interaction terms in a sequential manner.
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CEO of Professional Science Editing for Scientists @ prosciediting.com