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The interaction of small molecules with DNA plays an essential role in many biological processes.
Until now, the interaction of small interference RNA (siRNA) with graphene materials has not been elucidated.
Moreover, the interaction of small organic molecules with the Renilla luciferase was studied using molecular dynamics simulations.
Hence, the interaction of small molecules with DNA has attracted in particular a great deal of attention.
Computational approaches such as docking confer interaction of small molecules with structural macromolecules and thereby hit identification and lead optimization.
The theoretical analysis proposed in this study, therefore, may be useful to understand interaction of small molecules with deoxyribonucleic acids.
Similar(32)
Here I propose that the interaction of small-scale convection in the asthenosphere with the base of the continental lithosphere can create intermittent vertical displacements of the surface with magnitude of a few hundreds of meters at the continental margin.
The interaction of small-scale relative displacements or microslip at the contact surfaces and sharp gradients in the near-surface contact stress field drives a damage process known as fretting.
Furthermore, we show that this assay permits us to study the interaction of small-molecule compounds with aggregates in situations in which the ThT assay fails.
Cell surface interactions of small molecules, however, are clearly important, especially for their uptake into cells15.
Previous studies have focused on high-affinity interactions of small molecules with cytoplasmic proteins, resulting in underrepresentation of cell-surface proteins in these studies14.
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