This study highlights the potential value of C3HeB/FeJ mice for non-clinical efficacy testing, especially for investigating the interaction of lesion pathology and drug effect.
The exact interaction of AD pathology and sex steroids is complex and not well understood, though a role for sex steroids in the epidemiology and pathology of AD is undeniable.
Notably, there is a trend for higher levels of basal OCR and ATP turnover with increased age (in the control and the AD groups with a similar slope of the trend lines, indicating no interaction of AD pathology with the age trends) and disease progression (lower MMSE score).
One possible explanation is that the increase in BACE1 in SAD results from the interaction of Alzheimer pathology with diverse factors associated to aging, such as oxidative stress, inflammatory changes or microRNA dysregulation, conditions known to increase BACE1 expression and activity in cell culture [ 12, 26, 50, 55].
The interaction of various medical pathologies with age-related body changes results in a physiologic change characterized by decreased ability to respond to stressors.
At any rate, these considerations revolve around the interaction of different neurodegenerative pathologies and do not relate to the value of Aβ imaging to accurately measure the presence of Aβ in the brain.
It may be an interesting subject for future studies to examine the effect of the ApoE genotype on the interaction of different brain pathologies associated with Alzheimer's disease.
However, the details of the interaction between mitochondrial toxins, progression of pathology, and α-syn aggregation are not fully established.
In "The Great God Pan," an oblique but deeply affecting play about the interaction of identity, psychology and pathology, Jamie's sense of general well-being is destabilized by the discovery that he may — or then again, may not — have been the victim of childhood sexual abuse.
As a consequence, research into the mechanistic connection between apoE4 and LOAD has focused on delineating the interaction of apoE with Aß pathology.
