Sentence examples for interaction of mutations from inspiring English sources

Application of our improved measure of biological information to evolution on two-locus, two-allele fitness landscapes demonstrates that mutual information between loci reflects epistatic interaction of mutations.

A document on assessing functional interaction of mutations.

We also investigated epistasis (E) [ 29], the interaction of mutations, and its relationship with plasticity.

Epistasis, the non-additive interaction of mutations at multiple loci, plays a major role when resistance to antibiotics requires the sequential substitution of multiple mutations.

By contrast, digenic inheritance occurs in cases where the interaction of mutations in two different genes is required for the expression of the clinical phenotype.

Here we report our study demonstrating the interaction of mutations in both IRA2 in yeast and Nf1 in murine hematopoietic cells with the cellular consequences of HQ exposure.

These recent results emphasize the complex interaction of mutation, recombination and natural selection in determining the pattern of base composition and codon usage in a genome, as well as suggest a possible role of stabilizing selection.

It should be acknowledged that background selection and genetic hitchhiking deal with groups of neighboring mutations from the same locus (Hill and Robertson 1966; Stephan 2010), whereas Fisher, Wright, and later researchers considered interactions of mutations in a few loci (Fisher 1930; Wright 1965; Bodmer and Felsenstein 1967; Gavrilets and Hastings 1994).

Kinase-impaired BRAF mutants showed a significant association with concomitant activating KRAS or NRAS mutations, but not PIK3CA mutations, supporting the reported interaction of these mutations.

However, even though some other amino acids are more hydrophobic than glutamine, only the substitution of Q10Y stabilized TtAG; therefore, we suggest that a combination of hydrogen bonding and hydrophobic interactions of mutation Q10Y resulted in improved thermostability for TtAG.

To investigate the interaction of gene mutations in the pathogenesis of adult AML, a complete mutational screening of 17 other genes was performed in all 500 patients (Table 3).