Sentence examples for interaction of death from inspiring English sources

Stimulation of Fas results in the oligomerization of its receptors and the recruitment of the adaptor molecule FADD through the interaction of death domains from both parts, which results in the recruitment of procaspase-8 and the formation of DISC.

Activation-induced cell death (AICD) is mediated by the interaction of death factors and their receptors and plays an important role in immune system homeostasis.

Insights into the mechanisms of interaction of death-fold domains will be useful to design strategies for specific modulation of complex formation and might lead to novel therapeutic applications.

For IRAK-1 it has been suggested that an intramolecular interaction of the death domain with the end of its CTD keeps IRAK-1 in a silent mode before phosphorylation events trigger its activation [ 29].

One involves the interaction of a death receptor such as the tumor necrosis factor receptor-1 (TNFR1) or the Fas receptor with its ligand and the second pathway depends on the participation of mitochondria.

The extrinsic pathway involves the interaction of a death receptor including Fas and TNF receptor superfamily members and ligands, and the intrinsic pathway involves the mitochondria that operate in both p53-dependent and independent manner [26][27].

Interaction of a death ligand to its corresponding receptor leads to activation of initiator caspase-8.

FLIP associates with FADD by homophilic interaction of the death effector domains (DED) contained within each molecule [ 13].

One pathway involves interaction of a death receptor, such as the TNF- or Fas-receptors with their respective ligands, and the second is mitochondria-dependent.

In previous studies by our group, sTRAIL had activity against glioma cells in vitro and demonstrated the interaction of the death and survival pathways in modulating the apoptotic response.

Transmembrane receptor -mediated interactions consisting of death receptors (such as Fas), which are members of the tumour necrosis factor (TNF) receptor gene superfamily [ 21], are reported to be involved in initiation of apoptosis by the extrinsic pathway.