Reviewer's report 3 – Dr. Georgy Karev (nominated by Dr. Peter Olofsson) This work continues a recent paper of the same author's team [ 1], where a mathematical model of interaction and competition of many RNA polymerases transcribing simultaneously a DNA locus, was formulated and developed.
This could imply that such recurrent axon collaterals connect functionally different sets of MSN and provide a way of interaction or competition between such populations of neurons.
It has been reported that there are at least two kinds of interaction – competition or complement – among the isoforms of GalNAc-Ts, as proven by experiments in vitro (Brockhausen et al, 1990; Bennett et al, 1998).
These parameters influence both the substrate-APC/CCdc20 interaction and the effect of competition for limited amounts of APC/CCdc20.
Significant main effects of tympanic temperature (P < 0.001), day of the competition (P = 0.018), and a tympanic temperature ∗ day of competition interaction (P < 0.001) were used to predict minor lapses in attention.
General Linear Model analysis was conducted to predict minor lapses in attention (Omnibus Test P < 0.001) and resulted in significant main effects for tympanic temperature (P < 0.001), day of the competition (P = 0.018), and a tympanic temperature ∗ day of competition interaction (P < 0.001).
However, we cannot exclude the possibility that sperm sperm interactions influence the outcome of competition between comp-1 and wild-type cells.
However, interactions between different forms of competition and environmental variation complicate efforts to understand the link between density dependence and evolutionary and ecological processes (Begon et al. 2005; Aboagye-Antwi et al. 2010).
We approach the quasispecies as an ecosystem, what implies that the fitness of each viral phenotype or virus variant results from the combination of its intrinsic properties (collected in a maximum growth rate parameter) and those resulting from its interactions (interaction coefficients, negative in the case of competition and positive for cooperation) with the other variants.
The data series on cocaine and heroin possession offences in NSW provide an illustrative example of the use of the heroin shortage natural experiment to confirm a long-standing theory of interaction or competition between these two markets.
