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In this study, we employed analytical ultracentrifugation and steady-state fluorescence spectroscopy to characterize the interaction of a potential new anticancer drug, AG1478-mesylate, with plasma proteins in a suspension of normal serum albumin (NSA).
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In particular, it is important to understand the interactions of a potential vaccine with antigen presenting cells (APCs) of the immune system.
Supported by significant correlation values, this observation is a confirmation of our original assumption that protein interactions are dominated by the highest scoring domain interactions, while high scoring domain interactions indicate the presence of a potential protein interaction.
While this is appealing as it relates to the traditional way of assessing the significance of an interaction term, a potential issue could be the narrow null distributions for higher order interactions.
A study of 38 species showed the importance of the interaction of a low osmotic potential and cell wall properties in maintaining growth.
The species specificity of Cdc7-Dbf4 isteraction is a potential area to exploit for the development of anti-mycotic drugs.
This mode of protein-DNA interaction provides a potential target for future antimicrobial drug design.
The CBAP-ZAP70 interaction implies a potential involvement of CBAP in TCR signaling, which prompted us to study the potential function of CBAP in T-cell development.
During the simplest of interactions with a potential love-interest, my brain is working overtime.
These issues were raised in a recent study (28, 30), which suggested that 'errors' of the type 'wrong protein' and 'wrong organism', among others, are not uncommon, and that the annotation of complexes as sets of spoke-expanded binary interactions is a potential source of concern.
zFurthermore, an interaction of two potential binding partners in the used yeast system leads to the association of the DNA binding and activation domains thus forming a chimeric, functional Gal4 transcription factor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com